Open AccessLocal accumbens in vivo imaging during deep brain stimulation reveals a strategy-dependent amelioration of hedonic feeding
Author(s) -
Hemmings Wu,
Bina Kakusa,
Sophie Neuner,
Daniel J. Christoffel,
Boris D. Heifets,
Robert C. Malenka,
Casey H. Halpern
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2109269118
Subject(s) - deep brain stimulation , nucleus accumbens , overeating , stimulation , neuroscience , in vivo , medium spiny neuron , brain stimulation reward , medicine , psychology , biology , striatum , dopamine , obesity , microbiology and biotechnology , disease , parkinson's disease
Significance Impulsive overeating is a common, disabling feature of eating disorders. Calcium imaging using fiber photometry has emerged as an in vivo methodology to measure neuronal population activity immune to electrical stimulation artifact from deep brain stimulation (DBS). Thus, when used simultaneously, calcium imaging can elucidate poorly understood DBS mechanisms. We show that nucleus accumbens D1 medial spiny calcium signaling increases in preparation of hedonic feeding of high-fat food. Further, responsive, over continuous, DBS strategies effectively disrupt this activity leading to decreased consumption. Implementation of this methodology to better understand mechanisms of these and other forms of neuromodulation for various indications may help advance the field to identify novel therapeutic targets with applications extending beyond obesity.