Open AccessThe genetic source tracking of human urinary exosomes
Author(s) -
Qingfu Zhu,
Liming Cheng,
Chunyu Deng,
Liu Huang,
Jiaoyuan Li,
Yong Wang,
Meng Li,
Qinsi Yang,
Xianjun Dong,
Jianzhong Su,
Luke P. Lee,
Fei Liu
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2108876118
Subject(s) - microvesicles , biology , liquid biopsy , gene , immune system , cell , rna , nanoparticle tracking analysis , exosome , computational biology , microbiology and biotechnology , microrna , genetics , cancer
The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine.