Open AccessAstrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation
Author(s) -
Sivaprakasam R. Saroja,
Kirill Gorbachev,
Julia Tcw,
Alison M. Goate,
Ana C. Pereira
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2108870119
Subject(s) - hyperphosphorylation , tau protein , astrocyte , microbiology and biotechnology , apolipoprotein e , neurodegeneration , tauopathy , biology , alzheimer's disease , neuroscience , medicine , phosphorylation , central nervous system , disease