Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes | Zendy

Yanfeng He | Zendy; Shigeo Sato | Zendy; Chieri TomomoriSato | Zendy; Shiyuan Chen | Zendy; Zach H. Goode | Zendy; Joan Conaway | Zendy; Ronald Conaway | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes

Author(s) -

Yanfeng He,

Shigeo Sato,

Chieri TomomoriSato,

Shiyuan Chen,

Zach H. Goode,

Joan Conaway,

Ronald Conaway

Publication year - 2021

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2108751118

Subject(s) - mediator , transcription factor , atf6 , enhancer , rna polymerase ii , biology , activating transcription factor , promoter , microbiology and biotechnology , gene , unfolded protein response , endoplasmic reticulum , genetics , gene expression

The bZIP transcription factor ATF6α is a master regulator of endoplasmic reticulum (ER) stress response genes. In this report, we identify the multifunctional RNA polymerase II transcription factor Elongin as a cofactor for ATF6α-dependent transcription activation. Biochemical studies reveal that Elongin functions at least in part by facilitating ATF6α-dependent loading of Mediator at the promoters and enhancers of ER stress response genes. Depletion of Elongin from cells leads to impaired transcription of ER stress response genes and to defects in the recruitment of Mediator and its CDK8 kinase subunit. Taken together, these findings bring to light a role for Elongin as a loading factor for Mediator during the ER stress response.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research