Open AccessThe nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway
Author(s) -
Ana R. Moshkovsky,
Marc W. Kirschner
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2108408119
Subject(s) - axin2 , wnt signaling pathway , computational biology , biology , gene , gene regulatory network , genetics , gene expression
Significance The mystery of two functionally redundant Axin genes in all vertebrates can now be explained by the demonstration that they form a nested proteostatic and transcriptional feedback system that confers regulatory options in different developmental settings, a form of dynamic versatility that may explain the widespread occurrence of closely related seemingly redundant genes with similar functions.