The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway | Zendy

Ana R Moshkovsky | Zendy; Marc W. Kirschner | Zendy

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The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway

Author(s) -

Ana R Moshkovsky,

Marc W. Kirschner

Publication year - 2022

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2108408119

Subject(s) - axin2 , wnt signaling pathway , computational biology , biology , gene , gene regulatory network , genetics , gene expression

Significance The mystery of two functionally redundant Axin genes in all vertebrates can now be explained by the demonstration that they form a nested proteostatic and transcriptional feedback system that confers regulatory options in different developmental settings, a form of dynamic versatility that may explain the widespread occurrence of closely related seemingly redundant genes with similar functions.

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