Open AccessRecurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2
Author(s) -
Wenshu Luo,
Matteo Egger,
Andor Domonkos,
Lin Que,
David Lukacsovich,
Natalia Andrea CruzOchoa,
Szilárd Szőcs,
Charlotte Seng,
Antónia Arszovszki,
Eszter Sipos,
Irmgard Amrein,
Jochen Winterer,
Tamás Lukacsovich,
János Szabadics,
David P Wolfer,
Csaba Varga,
Csaba Földy
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2108239118
Subject(s) - mossy fiber (hippocampus) , neuroscience , hippocampal formation , regulator , biology , sprouting , granule cell , microbiology and biotechnology , genetics , dentate gyrus , botany , gene
Significance Neurons have an exceptional capacity to grow axons and form synaptic circuits during development but not later life. In adults, the lack of circuit formation may support retention of skilled actions and memories but also limits regeneration and repair after injuries and in disorders. Research on developing and damaged neurons has revealed many molecules that help circuit formation and regeneration, and yet factors that could induce axon growth and synapse formation in adult brain neurons remain elusive. Here, we searched for such key molecules and find one that alone can induce complete circuit formation. After engineering a new circuit in adult mice, we also looked into its function and relevance for memories.