Open AccessRegional synapse gain and loss accompany memory formation in larval zebrafish
Author(s) -
William P. Dempsey,
Zhuowei Du,
Andtochiy,
Colton D. Smith,
Karl Czajkowski,
Andrey Andreev,
Drew N. Robson,
Jennifer M. Li,
Serina Applebaum,
Thai V. Truong,
Carl Kesselman,
Scott E. Fraser,
Don W. Arnold
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2107661119
Subject(s) - neuroscience , synapse , excitatory postsynaptic potential , zebrafish , memory formation , amygdala , associative learning , biology , hippocampal formation , inhibitory postsynaptic potential , biochemistry , gene
Significance Imaging of labeled excitatory synapses in the intact brain before and after classical conditioning permits a longitudinal analysis of changes that accompany associative memory formation. When applied to midlarval stage zebrafish, this approach reveals adjacent regions of synapse gain and loss in the lateral and medial pallium, respectively. Such major structural changes could account for the robust nature of memory formation from classical conditioning.