Open AccessExtracellular vesicles from triple negative breast cancer promote pro-inflammatory macrophages associated with better clinical outcome
Author(s) -
Mercedes Tkach,
Jessie Thalmensi,
Eleonora Timperi,
Paul Gueguen,
Nathalie Névo,
Eleonora Grisard,
Philémon Sirven,
Federico Cocozza,
Alizée Gouronnec,
Lorena MartínJaular,
Mabel Jouve San-Roman,
Fabien Delisle,
Nicolas Manel,
Derek C. Rookhuizen,
Coralie L. Guerin,
Vassili Soumelis,
Emanuela Romano,
Élodie Segura,
Clotilde Théry
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2107394119
Subject(s) - triple negative breast cancer , proinflammatory cytokine , extracellular vesicles , immune system , breast cancer , extracellular , inflammation , cancer research , human breast , cancer , microvesicles , macrophage , immunology , medicine , biology , microbiology and biotechnology , in vitro , biochemistry , microrna , gene
Significance Our work uncovers mechanisms by which tumor cells impact tumor-associated macrophages in human triple-negative breast cancer. Via extracellular vesicles (EVs), these tumors promote macrophages with proinflammatory features, correlated with better clinical outcome. Our results suggest exploration of these EVs as tools, alone, or in combination with other therapies, to promote a favorable environment for the generation of anti-tumor immune responses.