Goal discrimination in hippocampal nonplace cells when place information is ambiguous | Zendy

Lu Zhang | Zendy; Stephanie M. Prince | Zendy; Abigail L. Paulson | Zendy; Annabelle C. Singer | Zendy

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Goal discrimination in hippocampal nonplace cells when place information is ambiguous

Author(s) -

Lu Zhang,

Stephanie M. Prince,

Abigail L. Paulson,

Annabelle C. Singer

Publication year - 2022

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2107337119

Subject(s) - place cell , hippocampal formation , neuroscience , coding (social sciences) , computer science , modulation (music) , biology , psychology , physics , mathematics , statistics , acoustics

Significance Goal-directed spatial navigation has been found to rely on hippocampal neurons that are spatially modulated. We show that “nonplace” cells without significant spatial modulation play a role in discriminating goals when environmental cues for goals are ambiguous. This nonplace cell activity is performance-dependent and is modulated by gamma oscillations. Finally, nonplace cell goal discrimination coding fails in a mouse model of Alzheimer’s disease (AD). Together, these results show that nonplace cell firing can signal unique task-relevant information when spatial information is ambiguous; these signals depend on performance and are absent in a mouse model of AD.

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