Open AccessPreferential and persistent impact of acute HIV-1 infection on CD4+iNKT cells in colonic mucosa
Author(s) -
Dominic PaquinProulx,
Kerri G. Lal,
Yuwadee Phuang-Ngern,
Matthew Creegan,
Andrey Tokarev,
Suchada Suhkumvittaya,
Aljawharah Alrubayyi,
Eugène Kroon,
Suteeraporn Pinyakorn,
Bonnie M. Slike,
Diane L. Bolton,
Shelly J. Krebs,
Leigh Anne Eller,
Chayada Sajjaweerawan,
Amélie Pagliuzza,
Nicolas Chomont,
Rungsun Rerknimitr,
Nitiya Chomchey,
Nittaya Phanuphak,
Mark S. de Souza,
Nelson L. Michael,
Merlin L. Robb,
Jintanat Ananworanich,
Johan K. Sandberg,
Michael A. Eller,
Alexandra Schuetz,
study groups
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2104721118
Subject(s) - immunology , in vitro , biology , natural killer t cell , intestinal mucosa , viral load , peripheral blood mononuclear cell , immune system , human immunodeficiency virus (hiv) , t cell , medicine , biochemistry
Significance Evidence suggests that HIV-1 disease progression is determined in the early stages of infection. Here, preinfection invariant natural killer T (iNKT) cell levels were predictive of the peak viral load during acute HIV-1 infection (AHI). Furthermore, iNKT cells were preferentially lost in AHI. This was particularly striking in the colonic mucosa, where iNKT cells were depleted more profoundly than conventional CD4 + T cells. The initiation of antiretroviral therapy during AHI-prevented iNKT cell dysregulation in peripheral blood but not in the colonic mucosa. Overall, our results support a model in which iNKT cells are early and preferential targets for HIV-1 infection during AHI.