Expression of Hv1 proton channels in myeloid-derived suppressor cells (MDSC) and its potential role in T cell regulation | Zendy

Juan J. Alvear-Arias | Zendy; Christian A. Carrillo-Soto | Zendy; Javiera Villar | Zendy; Richard García-Betancourt | Zendy; Antonio Peña-Pichicoi | Zendy; Audry Fernández | Zendy; Miguel Fernández | Zendy; Emerson M. Carmona | Zendy; Amaury Pupo | Zendy; Alan Neely | Zendy; Osvaldo Álvarez | Zendy; José Antonio Gárate | Zendy; Héctor Barajas-Martínez | Zendy; H. Peter Larsson | Zendy; Angélica López-Rodríguez | Zendy; Ramón Latorre | Zendy; Carlos González | Zendy

Open Access

Expression of H_v1 proton channels in myeloid-derived suppressor cells (MDSC) and its potential role in T cell regulation

Author(s) -

Juan J. Alvear-Arias,

Christian A. Carrillo-Soto,

Javiera Villar,

Richard García-Betancourt,

Antonio Peña-Pichicoi,

Audry Fernández,

Miguel Fernández,

Emerson M. Carmona,

Amaury Pupo,

Alan Neely,

Osvaldo Álvarez,

José Antonio Gárate,

Héctor Barajas-Martínez,

H. Peter Larsson,

Angélica López-Rodríguez,

Ramón Latorre,

Carlos González

Publication year - 2022

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2104453119

Subject(s) - flow cytometry , nadph oxidase , myeloid derived suppressor cell , immune system , chemistry , immunosuppression , population , microbiology and biotechnology , reactive oxygen species , biology , immunology , suppressor , biochemistry , medicine , gene , environmental health

Significance Immunosuppression by myeloid-derived suppressor cells (MDSC), especially near tumor surfaces, involves the extracellular production of reactive oxygen species (ROS). ROS generation in MDSC occurs during the oxidation of NADPH to NADP+, which NOX2 catalyzes. ROS react with the T cell receptor complex, abolishing the antigen presentation, which blocks the immune system elimination of the tumor cells. Extrusion of protons from MDSC by voltage-gated proton channel (Hv 1) sustains ROS production. Here, we demonstrate the expression of Hv 1 in mouse MDSC. In this way, Hv 1 present in MDSC becomes a potential cancer therapeutic target since its inhibition seems to diminish immunosuppression activity in the tumoral microenvironment, allowing cancer cells to be attacked by the immune system.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research