Open AccessExpression of Hv1 proton channels in myeloid-derived suppressor cells (MDSC) and its potential role in T cell regulation
Author(s) -
Juan J. Alvear-Arias,
Christian Carrillo,
Javiera Villar,
Richard García-Betancourt,
Antonio Peña-Pichicoi,
Audry Fernández,
Miguel Ángel Lorenzo Fernández,
Emerson M. Carmona,
Amaury Pupo,
Alan Neely,
Osvaldo Álvarez,
José Antonio Gárate,
Héctor Barajas-Martínez,
H. Peter Larsson,
Angélica Lopez-Rodriguez,
Ramón Latorre,
Carlos González
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2104453119
Subject(s) - flow cytometry , nadph oxidase , myeloid derived suppressor cell , immune system , chemistry , immunosuppression , population , microbiology and biotechnology , reactive oxygen species , biology , immunology , suppressor , biochemistry , medicine , gene , environmental health
Significance Immunosuppression by myeloid-derived suppressor cells (MDSC), especially near tumor surfaces, involves the extracellular production of reactive oxygen species (ROS). ROS generation in MDSC occurs during the oxidation of NADPH to NADP+, which NOX2 catalyzes. ROS react with the T cell receptor complex, abolishing the antigen presentation, which blocks the immune system elimination of the tumor cells. Extrusion of protons from MDSC by voltage-gated proton channel (Hv 1) sustains ROS production. Here, we demonstrate the expression of Hv 1 in mouse MDSC. In this way, Hv 1 present in MDSC becomes a potential cancer therapeutic target since its inhibition seems to diminish immunosuppression activity in the tumoral microenvironment, allowing cancer cells to be attacked by the immune system.