IFP35 family proteins promote neuroinflammation and multiple sclerosis | Zendy

Xizhong Jing | Zendy; Yongjie Yao | Zendy; Danning Wu | Zendy; Hao Hong | Zendy; Xu Feng | Zendy; Na Xu | Zendy; Yingfang Liu | Zendy; Huanhuan Liang | Zendy

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IFP35 family proteins promote neuroinflammation and multiple sclerosis

Author(s) -

Xizhong Jing,

Yongjie Yao,

Danning Wu,

Hao Hong,

Xu Feng,

Na Xu,

Yingfang Liu,

Huanhuan Liang

Publication year - 2021

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2102642118

Subject(s) - neuroinflammation , multiple sclerosis , experimental autoimmune encephalomyelitis , microglia , pathogenesis , mechanism (biology) , central nervous system , neuroscience , disease , medicine , immunology , biology , pathology , inflammation , philosophy , epistemology

Significance Multiple sclerosis (MS) is a complex neuroinflammatory disorder that constitutes the major cause of nontraumatic disability in young adults. However, the underlying mechanism of this disease remains obscure. Here, we identified NMI and IFP35 as factors critical in the progress of MS and experimental autoimmune encephalomyelitis, as their dysregulation activates both microglia in the central nervous system and T cells in the periphery. This study expands our understanding of the pathogenesis of MS and aims to provide potential diagnostic and therapeutic targets.

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