RyR-mediated Ca2+release elicited by neuronal activity induces nuclear Ca2+signals, CREB phosphorylation, and Npas4/RyR2 expression | Zendy

Pedro Lobos | Zendy; Alex Córdova | Zendy; Ignacio Vega-Vásquez | Zendy; Omar A. Ramírez | Zendy; Tatiana Adasme | Zendy; Jorge Toledo | Zendy; Mauricio Cerda | Zendy; Steffen Härtel | Zendy; Andrea Paula-Lima | Zendy; Cecilia Hidalgo | Zendy

Open Access

RyR-mediated Ca²⁺release elicited by neuronal activity induces nuclear Ca²⁺signals, CREB phosphorylation, and Npas4/RyR2 expression

Author(s) -

Pedro Lobos,

Alex Córdova,

Ignacio Vega-Vásquez,

Omar A. Ramírez,

Tatiana Adasme,

Jorge Toledo,

Mauricio Cerda,

Steffen Härtel,

Andrea Paula-Lima,

Cecilia Hidalgo

Publication year - 2021

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2102265118

Subject(s) - ryanodine receptor , creb , ryanodine receptor 2 , hippocampal formation , phosphorylation , chemistry , microbiology and biotechnology , synaptic plasticity , neuroscience , nucleus , biology , medicine , biochemistry , transcription factor , receptor , gene , intracellular

Significance The expression of genes involved in hippocampal synaptic plasticity, learning, and memory requires that Ca2+ signals generated in spines, dendrites, or the soma by neuronal stimulation reach the nucleus. Here, we report that stimulation of hippocampal neurons induces Ca2+ release mediated by RyR2 channels, which contributes to nuclear Ca2+ signal generation. Suppression of RyR-mediated Ca2+ release inhibited the activity-induced phosphorylation of the nuclear transcriptional regulator CREB and the expression of the Npas4 transcription factor and RyR2, which play crucial roles in hippocampal memory processes. We propose that RyR-mediated Ca2+ release induced by neuronal stimulation, by promoting the sequential generation of nuclear Ca2+ signals, CREB phosphorylation, and Npas4/RyR2 up-regulation, plays a significant role in hippocampal synaptic plasticity and spatial memory processes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research