Open AccessIncreasing and decreasing interregional brain coupling increases and decreases oscillatory activity in the human brain
Author(s) -
Alejandra Sel,
Lennart Verhagen,
Katharina Angerer,
Raluca David,
Miriam C. Klein-Flügge,
Matthew F. S. Rushworth
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2100652118
Subject(s) - neuroscience , transcranial magnetic stimulation , rhythm , motor cortex , premotor cortex , stimulation , postsynaptic potential , alpha (finance) , brain activity and meditation , neuroplasticity , psychology , beta rhythm , primary motor cortex , magnetoencephalography , beta (programming language) , brain stimulation , biology , physics , electroencephalography , dorsum , computer science , developmental psychology , anatomy , biochemistry , construct validity , receptor , acoustics , programming language , psychometrics
Significance Oscillatory activity is prominent in the brain, and one hypothesis is that it is, in part, due to the nature of coupling or interaction patterns between brain areas. We tested this hypothesis by manipulating the strength of coupling between two brain regions (ventral premotor cortex, PMv, and motor cortex, M1) in two directions (increase or decrease) while carefully controlling for the impact each manipulation had on activity in each area. We looked at the PMv–M1 connection because it is the major cortical route by which prefrontal cortex might influence, inhibit, and curtail action-related activity in M1. Manipulating PMv–M1 coupling in accordance with Hebbian-like spike-timing–dependent plasticity resulted in changes in beta and theta frequencies linked to action control.