Open AccessCREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila
Author(s) -
Hsuan-Wen Lin,
ChunChao Chen,
J. Steven de Belle,
Tim Tully,
AnnShyn Chiang
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2100624118
Subject(s) - creb , biology , transcription factor , microbiology and biotechnology , gene expression , long term memory , cyclic amp response element binding protein , neuroscience , gene , transcription (linguistics) , genetics , linguistics , philosophy , cognition
Significance Most animals record only labile memories of single events, whereas the formation of persistent long-term memories (LTMs) usually requires recurrent experiences. Our study distinguishes these different memory types through a deconvolution of molecular/biochemical processes within specific neurons of an identified memory circuit. A training-responsive gene activator, CREBA, engages paired DAL neurons in this circuit by promoting protein synthesis–dependent LTMs, which can otherwise be antagonized by CREBB repressor proteins. Increased CREBA expression or elevated membrane excitability enhances LTMs even after only one training cycle. These findings exemplify a circuit gating mechanism via cellular changes in specific single neurons to distinguish one-time experiences from multiple sessions of learning for storage as persistent memory.