Loss of function of a DMR6 ortholog in tomato confers broad-spectrum disease resistance | Zendy

Daniela Paula de Toledo Thomazella | Zendy; Kyungyong Seong | Zendy; Rebecca Mackelprang | Zendy; Douglas Dahlbeck | Zendy; Yu Geng | Zendy; Upinder Gill | Zendy; Tiancong Qi | Zendy; Julie Pham | Zendy; P.O. Giuseppe | Zendy; Clara Youngna Lee | Zendy; Arturo Ortega | Zendy; MyeongJe Cho | Zendy; Samuel F. Hutton | Zendy; Brian J. Staskawicz | Zendy

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Loss of function of a DMR6 ortholog in tomato confers broad-spectrum disease resistance

Author(s) -

Daniela Paula de Toledo Thomazella,

Kyungyong Seong,

Rebecca Mackelprang,

Douglas Dahlbeck,

Yu Geng,

Upinder Gill,

Tiancong Qi,

Julie Pham,

P.O. Giuseppe,

Clara Youngna Lee,

Arturo Ortega,

MyeongJe Cho,

Samuel F. Hutton,

Brian J. Staskawicz

Publication year - 2021

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2026152118

Subject(s) - oomycete , biology , arabidopsis , gene , plant disease resistance , plant immunity , phenotype , mutant , salicylic acid , pathogen , genetics , immune system , r gene , broad spectrum , function (biology) , microbiology and biotechnology , chemistry , combinatorial chemistry

Significance Susceptibility (S) genes are plant genes that facilitate pathogen infection. Inactivation of S genes has been considered a promising strategy to obtain broad-spectrum and durable resistance in crops. We characterized two orthologs of theArabidopsis S geneDMR6 in tomato:SlDMR6-1 andSlDMR6-2 . We show that SlDMR6-1, but not SlDMR6-2, is associated with plant immunity. Remarkably,Sldmr6-1 mutants display enhanced resistance to bacterial, oomycete, and fungal pathogens. This phenotype correlates with increased levels of the defense hormone salicylic acid (SA) and enhanced transcriptional activation of plant immune responses. We also demonstrate that SlDMR6-1 and SlDMR6-2 convert SA into its inactive form, 2,5-DHBA, indicating that they play a role in SA homeostasis.

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