Open AccessIncipient genome erosion and metabolic streamlining for antibiotic production in a defensive symbiont
Author(s) -
Taras Y. Nechitaylo,
Mario Sandoval-Calderón,
Tobias Engl,
Natalie Wielsch,
Diane M. Dunn,
Alexander Goesmann,
Erhard Strohm,
Aleš Svatoš,
Colin Dale,
Robert B. Weiss,
Martin Kaltenpoth
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2023047118
Subject(s) - biology , genome , gene , genetics , obligate , transcriptome , comparative genomics , microbiology and biotechnology , genomics , gene expression , ecology
Significance Genome reduction is commonly observed in bacteria of several phyla engaging in obligate nutritional symbioses with insects. In Actinobacteria, however, little is known about the process of genome evolution, despite their importance as prolific producers of antibiotics and their increasingly recognized role as defensive partners of insects and other organisms. Here, we show that “Streptomyces philanthi ,” a defensive symbiont of digger wasps, has a G+C-enriched genome in the early stages of erosion, with inactivating mutations in a large proportion of genes, causing dependency on its hosts for certain nutrients, which was validated in axenic symbiont cultures. Additionally, overexpressed catabolic and biosynthetic pathways of the bacteria inside the host indicate host–symbiont metabolic integration for streamlining and control of antibiotic production.