Open AccessGenetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors
Author(s) -
Valeska Helfinger,
Florian Freiherr von Gall,
Nina Henke,
Michael M. Kunze,
Tobias Schmid,
Flávia Rezende,
Juliana Heidler,
Ilka Wittig,
Heinfried H. Radeke,
Viola Marschall,
Karen E. Anderson,
Ajay M. Shah,
Simone Fulda,
Bernhard Brüne,
Ralf P. Brandes,
Katrin Schröder
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2020152118
Subject(s) - nox4 , nadph oxidase , hydrogen peroxide , reactive oxygen species , context (archaeology) , chemistry , biology , microbiology and biotechnology , cancer research , biochemistry , paleontology
Significance The stereotype of ROS produced by NADPH oxidases as cause of malignant diseases persists in a generalized manner. In fact, high levels of ROS formation could be harmful in the context of a disease process. This study demonstrates that loss of the NADPH oxidase Nox4, as a constitutive source of ROS, promotes cancerogen-induced formation of solid tumors. Accordingly, a certain tonic, constitutive low level of Nox4-derived hydrogen peroxide appears to reduce the risk of cancerogen-induced tumor formation.