Open AccessCellular-resolution gene expression profiling in the neonatal marmoset brain reveals dynamic species- and region-specific differences
Author(s) -
Yoshiaki Kita,
Hirozumi Nishibe,
Yan Wang,
Tsutomu Hashikawa,
Shunsuke Kikuchi,
U Mami,
Aya Yoshida,
Chihiro Yoshida,
Takashi Kawase,
Shin Ishii,
Henrik Skibbe,
Tomomi Shimogori
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2020125118
Subject(s) - marmoset , biology , gene expression , gene , gene expression profiling , regulation of gene expression , genetics , computational biology , paleontology
Significance The MGA contains a large gene expression dataset from the developing brain of the common marmoset. However, the data represent the gene expression patterns across the entire brain, and methods to isolate region-specific gene expression patterns will provide important information regarding primate brain structure, function, and cellular and molecular organization. We have developed a system, GePS, that systematically identifies genes expressed in selected regions of the common marmoset brain. Comprehensive, comparative gene expression analysis with mice revealed many genes with species- and region-specific expression. Moreover, by combining GePS with the gene expression comparison and cortical area projection mapping systems, we were able to provide further insight into the molecular organization of these species- and region-specific gene expression patterns.