English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Although the global hepatitis B virus (HBV) vaccination program has been overwhelmingly successful, it still carries 5% to 10% of nonresponders at risk for HBV infection. The key immunoregulatory factors preventing the desired humoral protection are still poorly defined. This work has not only addressed fundamental mechanisms of how lymph node sinus macrophages regulate immunogenicity of particle antigens like HBV vaccine but also suggested interleukin-1 receptor antagonist neutralization might be a viable strategy to boost antibody response in these nonresponders.

Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin