Open AccessViolet light suppresses lens-induced myopia via neuropsin (OPN5) in mice
Author(s) -
Xiaoyan Jiang,
Machelle T. Pardue,
Kiwako Mori,
Shigeto Ikeda,
Hidemasa Torii,
Shane P D'Souza,
Richard A. Lang,
Michio Ohta
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2018840118
Subject(s) - blue light , retinal , lens (geology) , microbiology and biotechnology , opsin , biology , ophthalmology , medicine , optics , rhodopsin , physics , paleontology
Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective effect on myopia. Recent reports have shown that short-wavelength visible violet light is the component of sunlight that appears to play an important role in preventing myopia progression in mice, chicks, and humans. The mechanism underlying this effect has not been understood. Here, we show that violet light prevents lens defocus-induced myopia in mice. This violet light effect was dependent on both time of day and retinal expression of the violet light sensitive atypical opsin, neuropsin (OPN5). These findings identify Opn5 -expressing retinal ganglion cells as crucial for emmetropization in mice and suggest a strategy for myopia prevention in humans.