The mRNA-destabilizing protein Tristetraprolin targets “meiosis arrester” Nppc mRNA in mammalian preovulatory follicles | Zendy

Guangyin Xi | Zendy; Lei An | Zendy; Wenjing Wang | Zendy; Jing Hao | Zendy; Qianying Yang | Zendy; Lizhu Ma | Zendy; Jinlun Lu | Zendy; Yue Wang | Zendy; Wenjuan Wang | Zendy; Wei Zhao | Zendy; Juan Liu | Zendy; Mingyao Yang | Zendy; Xiaodong Wang | Zendy; Zhenni Zhang | Zendy; Chao Zhang | Zendy; Meiqiang Chu | Zendy; Yuan Yue | Zendy; Fusheng Yao | Zendy; Meijia Zhang | Zendy; Jianhui Tian | Zendy

Open Access

The mRNA-destabilizing protein Tristetraprolin targets “meiosis arrester” Nppc mRNA in mammalian preovulatory follicles

Author(s) -

Guangyin Xi,

Lei An,

Wenjing Wang,

Jing Hao,

Qianying Yang,

Lizhu Ma,

Jinlun Lu,

Yue Wang,

Wenjuan Wang,

Wei Zhao,

Juan Liu,

Mingyao Yang,

Xiaodong Wang,

Zhenni Zhang,

Chao Zhang,

Meiqiang Chu,

Yuan Yue,

Fusheng Yao,

Meijia Zhang,

Jianhui Tian

Publication year - 2021

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2018345118

Subject(s) - oocyte , meiosis , messenger rna , microbiology and biotechnology , biology , ovarian follicle , oocyte activation , endocrinology , genetics , ovary , gene , embryo

Significance The fertility of female mammals depends upon the well-orchestrated progression of oocyte meiosis, the female germ cell division that is essential for haploid oocyte formation. In preovulatory follicles, how LH induces a decrease in CNP and its encoding mRNANppc , a prerequisite for oocyte meiotic resumption, remains an outstanding question to understand the mechanism that controls oocyte meiosis. The present study shows that TTP, an mRNA-destabilizing protein, is one of the regulatory components responsible for the LH-induced rapid decrease inNppc mRNA and oocyte meiotic resumption. This finding not only highlights the importance of posttranscriptional regulation in the follicle periphery to fine-tune oocyte meiosis but also provides an insight into CNP-dependent cGMP homeostasis in other physiological systems.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research