Open AccessStructure–function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions
Author(s) -
Larry W. Swanson,
Joel D. Hahn,
Olaf Sporns
Publication year - 2020
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2017733117
Subject(s) - forebrain , medial forebrain bundle , cognition , affect (linguistics) , neuroscience , psychology , function (biology) , bundle , biology , central nervous system , communication , striatum , dopamine , evolutionary biology , materials science , composite material
Significance The forebrain is required for generating mammalian voluntary and innate behaviors. Multiresolution consensus cluster analysis generated a panoramic, hierarchical view of rat intraforebrain structure–function subsystem organization, from the top level with just two relatively independent mirror image subsystems centered on either side of the brain, to over 90 bottom-level subsystems. Each top-level subsystem has two interconnected subsystems: one includes the medial forebrain bundle and integrates instinctive survival behaviors with relevant physiological responses and affect, whereas the other uses the lateral forebrain bundle and mediates voluntary behavior control, with associated cognition. The intraforebrain network is sexually dimorphic, and targeted computational lesions of nodes implicated in human Alzheimer’s disease and depression produce severe, differential, global network changes in males and females.