Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis | Zendy

Paula B. Donate | Zendy; Kalil Alves de Lima | Zendy; Raphael Sanches Peres | Zendy; Fausto Almeida | Zendy; Sandra Yasuyo Fukada | Zendy; Tarcı́lia Aparecida Silva | Zendy; Daniele C. Nascimento | Zendy; Nerry T. Cecílio | Zendy; Jhimmy Talbot | Zendy; Renê Donizeti Ribeiro de Oliveira | Zendy; Geraldo Aleixo Silva Passos | Zendy; José C. AlvesFilho | Zendy; Thiago M. Cunha | Zendy; Paulo LouzadaJúnior | Zendy; Foo Y. Liew | Zendy; Fernando Q. Cunha | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis

Author(s) -

Paula B. Donate,

Kalil Alves de Lima,

Raphael Sanches Peres,

Fausto Almeida,

Sandra Yasuyo Fukada,

Tarcı́lia Aparecida Silva,

Daniele C. Nascimento,

Nerry T. Cecílio,

Jhimmy Talbot,

Renê Donizeti Ribeiro de Oliveira,

Geraldo Aleixo Silva Passos,

José C. AlvesFilho,

Thiago M. Cunha,

Paulo LouzadaJúnior,

Foo Y. Liew,

Fernando Q. Cunha

Publication year - 2020

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2017120118

Subject(s) - proinflammatory cytokine , rheumatoid arthritis , gene knockdown , aryl hydrocarbon receptor , pathogenesis , arthritis , inflammation , immunology , medicine , microrna , mediator , microvesicles , cancer research , biology , transcription factor , cell culture , gene , genetics

Significance This report reveals a mechanism by which cigarette smoke (CS) could exacerbate local inflammatory disease. CS is a key environmental pollutant affecting millions of people globally and continues to be of considerable interest to the biomedical communities. We found that CS activates the AhR on Th17 cells, leading to the up-regulation ofmiR-132 , which is then packaged into extracellular vesicles that induce osteoclastogenesis via the suppression of Cox2 that catalyzes prostaglandins. Clinically, rheumatoid arthritis (RA) patients who smoke express a higher level ofmiRNA-132 compared to nonsmoking RA patients. This finding not only reveals a mechanism of CS signaling but also may provide a potential target for therapeutic intervention for inflammatory disease in general and RA in particular.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research