Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in polarized epithelial cells | Zendy

Stéphanie Lebreton | Zendy; Simona Paladino | Zendy; Dandan Liu | Zendy; Maria Nitti | Zendy; Julia von Blume | Zendy; Paolo Pinton | Zendy; Chiara Zurzolo | Zendy

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Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in polarized epithelial cells

Author(s) -

Stéphanie Lebreton,

Simona Paladino,

Dandan Liu,

Maria Nitti,

Julia von Blume,

Paolo Pinton,

Chiara Zurzolo

Publication year - 2021

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2014709118

Subject(s) - golgi apparatus , microbiology and biotechnology , calcium , biology , apical cell , chemistry , endoplasmic reticulum , biochemistry , cell , organic chemistry

Significance Our findings represent a fundamental advance in general understanding of the mechanisms of exocytosis in polarized epithelial cells that are crucial for the establishment and maintenance of epithelial cell polarity. Moreover, our data also improve the knowledge on the machinery regulating polarized trafficking of glycosylphosphatidylinositol-anchored proteins, a class of lipid-associated proteins playing diverse vital functions, unraveling an unexpected role of calcium in their apical sorting.

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