Open AccessExpression attenuation as a mechanism of robustness against gene duplication
Author(s) -
Diana Ascencio,
Guillaume Diss,
Isabelle GagArsenault,
Alexandre K. Dubé,
Alexander DeLuna,
Christian R. Landry
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2014345118
Subject(s) - gene duplication , gene , biology , gene dosage , genetics , functional divergence , gene expression , budding yeast , robustness (evolution) , gene family , saccharomyces cerevisiae
Significance Many studies have focused on the mechanisms of long-term retention of gene duplicates, such as the gain of functions or reciprocal losses. However, such changes are more likely to occur if the duplicates are maintained for a long period. This time span will be short if duplication is immediately deleterious. We measured the distribution of fitness effects of gene duplication for 899 genes in budding yeast. We find that gene duplication is more likely to be deleterious than beneficial. However, contrary to previous models, in general, gene duplication does not affect fitness by altering the organization of protein complexes. We show that expression attenuation may protect complexes from the effects of gene duplication.