TCRα reporter mice reveal contribution of dual TCRα expression to T cell repertoire and function | Zendy

Letitia Yang | Zendy; Burhan Jama | Zendy; Huawei Wang | Zendy; Lara Labarta-Bajo | Zendy; Elina I. Zúñiga | Zendy; Gerald P. Morris | Zendy

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TCRα reporter mice reveal contribution of dual TCRα expression to T cell repertoire and function

Author(s) -

Letitia Yang,

Burhan Jama,

Huawei Wang,

Lara Labarta-Bajo,

Elina I. Zúñiga,

Gerald P. Morris

Publication year - 2020

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2013188117

Subject(s) - t cell receptor , repertoire , function (biology) , t cell , dual (grammatical number) , microbiology and biotechnology , biology , immunology , immune system , art , literature

Significance This study utilizes novel transgenic reporter mice to definitively evaluate T cells coexpressing two T cell antigen receptors. These experiments demonstrate that T lymphocytes naturally coexpressing two different antigen receptors are significantly more abundant than previous estimates and that these cells have a previously unappreciated role in physiologic immune responses.

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