Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors

Significance Humans, like most diurnal species, utilize cone photoreceptors to enable daylight vision. They detect color, cover a wide range of light intensities, and sustain fast responsiveness to faithfully sample rapidly changing scenery. All of these features that allow us to accurately see the world depend on the ability of cones to transmit their light-evoked signals to the brain. For this, cones form functional contacts with their downstream neurons—a process known as “synaptic wiring.” The molecular mechanisms that mediate establishment of cone synaptic contacts are largely unknown. Our studies fill this gap by identifying a set of molecules involved in functional wiring of cones.