Molecular insights into the genome dynamics and interactions between core and acquired genomes of Vibrio cholerae | Zendy

Archana Pant | Zendy; Satyabrata Bag | Zendy; Bipasa Saha | Zendy; Jyoti Verma | Zendy; Pawan Kumar | Zendy; Sayantan Banerjee | Zendy; Bhoj Kumar | Zendy; Yashwant Kumar | Zendy; Anbumani Desigamani | Zendy; Suhrid Maiti | Zendy; Tushar Kanti Maiti | Zendy; S. K. Banerjee | Zendy; Rupak K. Bhadra | Zendy; Hemanta Koley | Zendy; Shanta Dutta | Zendy; G. Balakrish Nair | Zendy; Thandavarayan Ramamurthy | Zendy; Bhabatosh Das | Zendy

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Molecular insights into the genome dynamics and interactions between core and acquired genomes of Vibrio cholerae

Author(s) -

Archana Pant,

Satyabrata Bag,

Bipasa Saha,

Jyoti Verma,

Pawan Kumar,

Sayantan Banerjee,

Bhoj Kumar,

Yashwant Kumar,

Anbumani Desigamani,

Suhrid Maiti,

Tushar Kanti Maiti,

S. K. Banerjee,

Rupak K. Bhadra,

Hemanta Koley,

Shanta Dutta,

G. Balakrish Nair,

Thandavarayan Ramamurthy,

Bhabatosh Das

Publication year - 2020

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2006283117

Subject(s) - vibrio cholerae , mobile genetic elements , genome , biology , proteome , genetics , cholera , computational biology , gene , microbiology and biotechnology , bacteria

Significance Genome fluidity is directly associated with the emergence and evolution of many bacterial pathogens. Horizontally acquired genetic elements, which harbor fitness traits, are open source for the bacterial evolution. The genome ofVibrio cholerae is equipped with multiple mobile genetic elements (MGEs), which are crucial for disease development and survival. The present study engineered the genome of a well characterized clinicalV. cholerae strain N16961 and reported (i ) stability of MGEs in cholera pathogen, (ii ) interactions between the core genome and MGEs, and (iii ) role of MGEs in the modulation of cellular proteome. The engineered strain could be a potential candidate for understanding evolution of cholera pathogen and development of new therapeutic interventions.

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