Open AccessParcellation of the striatal complex into dorsal and ventral districts
Author(s) -
ShihYun Chen,
Kuan-Ming Lu,
Hsin-An Ko,
Ting-Hao Huang,
Janice Hsin-Jou Hao,
YuTing Yan,
Sunny LiYun Chang,
Sylvia Μ. Evans,
FuChin Liu
Publication year - 2020
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1921007117
Subject(s) - striatum , ventral striatum , basal ganglia , neuroscience , dorsum , direct pathway of movement , biology , psychology , anatomy , central nervous system , dopamine
Significance The striatum of the basal ganglia is divided into dorsal and ventral regions. The dorsal striatum regulates movement and cognition, whereas the ventral striatum modulates reward and emotion. The importance of striatal divisions also is reflected in neurological diseases as the dorsal and ventral striata are differentially targeted by Huntington’s disease, Parkinson’s disease, and drug addiction disorders. Despite the significance of these neurological differences, the neural mechanisms underlying the division of the striatum into the dorsal and ventral districts remain elusive. Here, we have identified two key genesNolz-1 andDlx1/2 , and the interactions betweenNolz-1 andDlx1/2 genes are critical for the developmental processes by which the striatum is divided into dorsal and ventral districts.
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