foxl3 , a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka | Zendy

Mariko Kikuchi | Zendy; T. Nishimura | Zendy; Satoshi Ishishita | Zendy; Yoichi Matsuda | Zendy; Minoru Tanaka | Zendy

Open Access

foxl3 , a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka

Author(s) -

Mariko Kikuchi,

T. Nishimura,

Satoshi Ishishita,

Yoichi Matsuda,

Minoru Tanaka

Publication year - 2020

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1918556117

Subject(s) - oogenesis , biology , germ cell , meiosis , microbiology and biotechnology , feminization (sociology) , spermatogenesis , gametogenesis , germ line development , genetics , oocyte , endocrinology , embryo , gene , embryogenesis , social science , sociology

Significance In teleost fish, unlike mammals, retinoic acid (RA) does not exert a conspicuous feminization effect of germ cells. Instead, in the teleost fish medaka,foxl3 serves as a germ cell-autonomous factor acting at the very beginning of the sexual fate decision. This study shows thatfoxl3 initiates oogenesis through two genetically independent pathways, meiosis and follicular development. One pathway, involvingrec8a , drives female-specific regulation of meiosis. The other, involvingfbxo47 , both directs follicular development and suppresses spermatogenesis commitment. The involvement of two evolutionarily conserved factors in oogenesis suggests the existence of an RA-independent pathway that promotes oogenesis, common in vertebrates. In addition, our findings reveal the timing of the establishment of germ cell feminization.

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