Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host | Zendy

William Perry | Zendy; Jeffrey M. Spraggins | Zendy; Jessica R. Sheldon | Zendy; Caroline M. Grunenwald | Zendy; David E. Heinrichs | Zendy; James E. Cassat | Zendy; Eric P. Skaar | Zendy; Richard M. Caprioli | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host

Author(s) -

William Perry,

Jeffrey M. Spraggins,

Jessica R. Sheldon,

Caroline M. Grunenwald,

David E. Heinrichs,

James E. Cassat,

Eric P. Skaar,

Richard M. Caprioli

Publication year - 2019

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1913991116

Subject(s) - siderophore , staphylococcus aureus , biology , pathogen , host (biology) , microbiology and biotechnology , vertebrate , microorganism , human pathogen , bacteria , ecology , genetics , gene

Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host-pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of Staphylococcus aureus siderophores across infectious foci, challenging the paradigm that the vertebrate host is a uniformly iron-depleted environment to invading microbes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research