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Use of a spontaneous adverse drug events database for identification of unanticipated drug benefits
Author(s) -
Brinker Allen,
Beitz Julie
Publication year - 2002
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1067/mcp.2002.120677
Subject(s) - adverse effect , drug , medicine , identification (biology) , database , drug reaction , intensive care medicine , pharmacology , bioinformatics , computer science , biology , botany
We describe an examination of a spontaneous adverse events database in an effort to identify agents with possible hitherto unknown antiangiogenic properties. The surrogate end point was abnormal wound healing. This analysis represents use of this database for identification of a possibly useful in vivo side effect. Through thoughtful choice of end points, we believe spontaneous adverse events databases have the capacity for hypothesis generation in a search for unanticipated beneficial drug properties. Clinical Pharmacology & Therapeutics (2002) 71 , 99–102; doi: 10.1067/mcp.2002.120677