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Analgesic effects of peripherally administered opioids in clinical models of acute and chronic inflammation
Author(s) -
Dionne Raymond A.,
Lepinski Allen M.,
Gordon Sharon M.,
Jaber Louay,
Brahim Jaime S.,
Hargreaves Kenneth M.
Publication year - 2001
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1067/mcp.2001.116443
Subject(s) - analgesic , medicine , morphine , opiate , placebo , fentanyl , anesthesia , peripheral , (+) naloxone , pharmacology , opioid , pathology , receptor , alternative medicine
A series of double‐blind, placebo‐controlled clinical trials demonstrated that low doses of morphine (0.4, 1.2, and 3.6 mg) administered into the intraligamentary space of a chronically inflamed hyperalgesic tooth produced a dose‐related naloxone‐reversible analgesia. This analgesic effect is mediated by a local mechanism in the inflamed tissue, because subcutaneous administration of a 1.2 mg dose of morphine failed to elicit an analgesic response. In contrast, submucosal administration of 1.2 mg morphine or 50 μg fentanyl to the site of extraction of an impacted third molar after the onset of acute pain failed to elicit an analgesic response despite demonstration of a sensitive bioassay. These data indicate that peripheral opioid analgesia can be evoked in a model of chronic, but not acute, inflammatory pain, suggesting a temporal dependent mechanism needed for the expression of peripheral opiate analgesia during inflammation in humans. Clinical Pharmacology & Therapeutics (2001) 70 , 66–73; doi: 10.1067/mcp.2001.116443