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Intravenous magnesium sulfate for bronchial hyperreactivity: A randomized, controlled, double‐blind study
Author(s) -
Schenk Peter,
Vonbank Karin,
Schnack Beate,
Haber Paul,
Lehr Stephan,
Smetana Ronald
Publication year - 2001
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1067/mcp.2001.114926
Subject(s) - magnesium , placebo , medicine , provocation test , saline , anesthesia , asthma , randomized controlled trial , gastroenterology , chemistry , pathology , alternative medicine , organic chemistry
Background Magnesium has been shown to be helpful in the treatment of acute exacerbations of asthma. Conflicting data exist concerning the effect of magnesium on bronchial hyperreactivity. Methods We performed a randomized, double‐blind, placebo‐controlled study to investigate the effect of intravenous magnesium sulfate on bronchial reactivity to metacholine in 30 subjects with bronchial hyperreactivity. Two days after baseline metacholine provocation, 20 subjects received 0.3 mmol/kg/h of intravenous magnesium sulfate and 10 subjects received normal saline solution. Metacholine provocation was repeated 30 minutes after the initiation of the magnesium or placebo infusion. Results The difference of the postinterventional minus the baseline provocative dose of metacholine required to decrease the forced expiratory volume in 1 second by 20% (PC 20 ) was significantly higher in the magnesium group compared with the placebo group (0.48 ± 0.46 mg/mL versus 0.05 ± 0.73 mg/mL, P = .028). In the magnesium group, the PC 20 significantly increased (from 0.83 ± 0.54 mg/mL to 1.31 ± 0.66 mg/mL, P = .0001), whereas there was no change in the placebo group (0.86 ± 0.52 mg/mL to 0.91 ± 0.54 mg/mL, P = .83). Conclusions In the magnesium group, 30% of the subjects reached a normal PC 20 compared with 10% in the placebo group. We conclude that intravenous magnesium sulfate significantly improved bronchial hyperreactivity and may serve as an adjunct to standard treatment. Clinical Pharmacology & Therapeutics (2001) 69 , 365–371; doi: 10.1067/mcp.2001.114926