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Pronounced effect of caprylocaproyl macrogolglycerides on nasal absorption of IS‐159, a peptide serotonin 1B/1D‐receptor agonist
Author(s) -
Dingemanse Jasper,
Soubrouillard Catherine,
Paris Jérôme,
Pisano Pascale,
Blin Olivier
Publication year - 2000
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1067/mcp.2000.108196
Subject(s) - nasal administration , pharmacokinetics , agonist , rhinorrhea , crossover study , tolerability , serotonin , medicine , pharmacology , absorption (acoustics) , receptor , anesthesia , chemistry , adverse effect , surgery , pathology , physics , alternative medicine , acoustics , placebo
Objectives This double‐blind, randomized, two‐way crossover study in 12 healthy male subjects investigated the influence of caprylocaproyl macrogolglycerides on the pharmacokinetics of IS‐159 (serotonin‐carboxylmethyleneoxy‐L‐tyrosylglycinamide), a peptide serotonin 1B/1D‐receptor agonist, after intranasal administration. Methods A dose of 4 mg IS‐159 was administered in a volume of 200 μL, once in the presence and once in the absence of 2% caprylocaproyl macrogolglycerides. Plasma concentrations of IS‐159 were measured over a period of 12 hours for determination of pharmacokinetic parameters. Systemic and local tolerability were assessed at regular time points, the latter by rhinoscopy and visual analog scales. Results Caprylocaproyl macrogolglycerides significantly increased the maximum plasma concentration (from 4.7 ± 1.7 to 48 ± 17 ng/mL) and the area under the plasma concentration–time curve (from 12 ± 4.7 to 56 ± 22 ng · h/mL) of IS‐159. The time to maximum concentration (15 to 20 minutes) and the elimination half‐life (2.0 to 2.3 hours) were not different between the two treatments. Rhinoscopic examination revealed no differences between treatments, but in the presence of caprylocaproyl macrogolglycerides subjects reported more local and systemic adverse events and on the visual analog scales greater nasal obstruction and rhinorrhea. Conclusion 2% caprylocaproyl macrogolglyceride markedly increased the absorption of IS‐159 through the nasal mucosa and elicited only mild irritant effects. Clinical Pharmacology & Therapeutics (2000) 68 , 114–121; doi: 10.1067/mcp.2000.108196