Composite vascular repair grafts via micro-imprinting and electrospinning | Zendy

Yuanyuan Liu | Zendy; Xiang Ke | Zendy; Haiping Chen | Zendy; Yu Li | Zendy; Qingxi Hu | Zendy

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Composite vascular repair grafts via micro-imprinting and electrospinning

Author(s) -

Yuanyuan Liu,

Xiang Ke,

Haiping Chen,

Yu Li,

Qingxi Hu

Publication year - 2015

Publication title -

aip advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.421

H-Index - 58

ISSN - 2158-3226

DOI - 10.1063/1.4906571

Subject(s) - electrospinning , composite number , materials science , chitosan , polyvinyl alcohol , scanning electron microscope , composite material , imprinting (psychology) , morphology (biology) , biomedical engineering , polymer , chemical engineering , chemistry , medicine , biochemistry , engineering , gene , genetics , biology

Composite vascular grafts formed by micro-imprinting and electrospinning exhibited improved mechanical properties relative to those formed by electrospinning alone. The three-layered composite grafts mimic the three-layered structure of natural blood vessels. The middle layer is made by micro-imprinting poly-p-dioxanone (PPDO), while the inner and outer layers are electrospun mixtures of chitosan and polyvinyl alcohol. The graft morphology is characterized with scanning electron microscopy. For constant graft thicknesses, the PPDO increases the mechanical strength. Cells cultivated on the vascular grafts adhere and proliferate better because of the natural, biological chitosan in the inner and outer layers. Overall, the composite scaffolds could be good candidates for blood vessel repair

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