Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia
Author(s) -
Kristi L. Watterberg,
Michele C. Walsh,
Lei Li,
Sanjay Chawla,
Carl T. D’Angio,
Ronald N. Goldberg,
Susan R. Hintz,
Matthew M. Laughon,
Bradley A. Yoder,
Kathleen A. Kennedy,
Georgia E. McDavid,
Conra Backstrom-Lacy,
Abhik Das,
Margaret M. Crawford,
Martin Keszler,
Gregory M. Sokol,
Brenda B. Poindexter,
Namasivayam Ambalavanan,
Anna Maria Hibbs,
William E. Truog,
Barbara Schmidt,
Myra H. Wyckoff,
Amir M. Khan,
Meena Garg,
Patricia R. Chess,
Anne Marie Reynolds,
Mohannad Moallem,
Edward F. Bell,
Lauritz R. Meyer,
Ravi M. Patel,
Krisa P. Van Meurs,
C. Michael Cotten,
Elisabeth C. McGowan,
Abbey C. Hines,
Stephanie L. Merhar,
Myriam PeraltaCarcelen,
Deanne E. Wilson-Costello,
Howard W. Kilbride,
Sara B. DeMauro,
Roy J. Heyne,
Ricardo A. Mosquera,
Girija Natarajan,
Isabell B. Purdy,
Jean Lowe,
Nathalie L. Maitre,
Heidi M. Harmon,
Laurie A. Hogden,
Ira AdamsChapman,
Sarah Winter,
William Malcolm,
Rosemary D. Higgins
Publication year - 2022
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa2114897
Subject(s) - bronchopulmonary dysplasia , medicine , gestational age , birth weight , placebo , hydrocortisone , mechanical ventilation , confidence interval , pediatrics , randomized controlled trial , anesthesia , low birth weight , pregnancy , genetics , alternative medicine , pathology , biology
Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development. Whether hydrocortisone treatment after the second postnatal week can improve survival without bronchopulmonary dysplasia and without adverse neurodevelopmental effects is unknown.
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