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Lutetium-177–PSMA-617 for Metastatic Castration-Resistant Prostate Cancer
Author(s) -
Oliver Sartor,
Johann S. de Bono,
Kim N.,
Karim Fizazi,
Ken Herrmann,
Kambiz Rahbar,
Scott T. Tagawa,
Luke T. Nordquist,
Nitin Vaishampayan,
Ghassan ElHaddad,
Chandler H. Park,
Tomasz M. Beer,
Alison Armour,
Wendy J. Pérez-Contreras,
Michelle DeSilvio,
Euloge Kpamegan,
Germo Gericke,
Richard A. Messmann,
Michael J. Morris,
Bernd J. Krause
Publication year - 2021
Publication title -
new england journal of medicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa2107322
Subject(s) - prostate cancer , medicine , castration , oncology , cancer research , prostate , cancer , hormone
Metastatic castration-resistant prostate cancer remains fatal despite recent advances. Prostate-specific membrane antigen (PSMA) is highly expressed in metastatic castration-resistant prostate cancer. Lutetium-177 ( 177 Lu)-PSMA-617 is a radioligand therapy that delivers beta-particle radiation to PSMA-expressing cells and the surrounding microenvironment.

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