Dipeptidyl Peptidase 4 Inhibition for Prophylaxis of Acute Graft-versus-Host Disease | Zendy

Sherif Farag | Zendy; Mohammad Abu Zaid | Zendy; Jennifer E. Schwartz | Zendy; Teresa C. Thakrar | Zendy; Ann J. Blakley | Zendy; Rafat Abonour | Zendy; Michael J. Robertson | Zendy; Hal E. Broxmeyer | Zendy; Shuhong Zhang | Zendy

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Dipeptidyl Peptidase 4 Inhibition for Prophylaxis of Acute Graft-versus-Host Disease

Author(s) -

Sherif Farag,

Mohammad Abu Zaid,

Jennifer E. Schwartz,

Teresa C. Thakrar,

Ann J. Blakley,

Rafat Abonour,

Michael J. Robertson,

Hal E. Broxmeyer,

Shuhong Zhang

Publication year - 2021

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa2027372

Subject(s) - medicine , sitagliptin , cumulative incidence , gastroenterology , transplantation , graft versus host disease , tacrolimus , incidence (geometry) , dipeptidyl peptidase 4 , hematopoietic stem cell transplantation , immunology , surgery , diabetes mellitus , endocrinology , insulin , type 2 diabetes , physics , metformin , optics

Dipeptidyl peptidase 4 (DPP-4; also known as CD26), a transmembrane receptor expressed on T cells, has a costimulatory function in activating T cells. In a mouse model, down-regulation of CD26 prevented graft-versus-host disease (GVHD) but preserved graft-versus-tumor effects. Whether inhibition of DPP-4 with sitagliptin may prevent acute GVHD after allogeneic stem-cell transplantation is not known.

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