Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers | Zendy

Eric J. Duncavage | Zendy; Molly C. Schroeder | Zendy; Michele O’Laughlin | Zendy; Roxanne Wilson | Zendy; Sandra MacMillan | Zendy; A.S. Bohan | Zendy; Scott Kruchowski | Zendy; John Garza | Zendy; Feiyu Du | Zendy; Andrew Hughes | Zendy; Josh Robinson | Zendy; Emma Hughes | Zendy; Sharon E. Heath | Zendy; Jack Baty | Zendy; Julie Neidich | Zendy; Matthew Christopher | Zendy; Meagan A. Jacoby | Zendy; Geoffrey L. Uy | Zendy; Robert S. Fulton | Zendy; Christopher A. Miller | Zendy; Jacqueline E. Payton | Zendy; Daniel C. Link | Zendy; Matthew J. Walter | Zendy; Peter Westervelt | Zendy; John F. DiPersio | Zendy; Timothy J. Ley | Zendy; David H. Spencer | Zendy

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Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers

Author(s) -

Eric J. Duncavage,

Molly C. Schroeder,

Michele O’Laughlin,

Roxanne Wilson,

Sandra MacMillan,

A.S. Bohan,

Scott Kruchowski,

John Garza,

Feiyu Du,

Andrew Hughes,

Josh Robinson,

Emma Hughes,

Sharon E. Heath,

Jack Baty,

Julie Neidich,

Matthew Christopher,

Meagan A. Jacoby,

Geoffrey L. Uy,

Robert S. Fulton,

Christopher A. Miller,

Jacqueline E. Payton,

Daniel C. Link,

Matthew J. Walter,

Peter Westervelt,

John F. DiPersio,

Timothy J. Ley,

David H. Spencer

Publication year - 2021

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa2024534

Subject(s) - myeloid leukemia , myelodysplastic syndromes , risk stratification , genome , biology , dna sequencing , computational biology , myeloid , whole genome sequencing , cancer genome sequencing , genetics , medicine , gene , cancer research , bone marrow , immunology

Genomic analysis is essential for risk stratification in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Whole-genome sequencing is a potential replacement for conventional cytogenetic and sequencing approaches, but its accuracy, feasibility, and clinical utility have not been demonstrated.

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