Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer | Zendy

Thierry André | Zendy; KaiKeen Shiu | Zendy; Tae Won Kim | Zendy; Benny Vittrup Jensen | Zendy; Lars Henrik Jensen | Zendy; Cornelis J.A. Punt | Zendy; Denis Smith | Zendy; Rocio GarcíaCarbonero | Zendy; Manuel Benavides | Zendy; Peter Gibbs | Zendy; Christelle de la Fouchardière | Zendy; Fernando Rivera | Zendy; Elena Élez | Zendy; Johanna C. Bendell | Zendy; Dung T. Le | Zendy; Takayuki Yoshino | Zendy; Eric Van Cutsem | Zendy; Ping Yang | Zendy; Mohammed Z.H. Farooqui | Zendy; Patricia Marinello | Zendy; Luis A. Díaz | Zendy

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Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer

Author(s) -

Thierry André,

KaiKeen Shiu,

Tae Won Kim,

Benny Vittrup Jensen,

Lars Henrik Jensen,

Cornelis J.A. Punt,

Denis Smith,

Rocio GarcíaCarbonero,

Manuel Benavides,

Peter Gibbs,

Christelle de la Fouchardière,

Fernando Rivera,

Elena Élez,

Johanna C. Bendell,

Dung T. Le,

Takayuki Yoshino,

Eric Van Cutsem,

Ping Yang,

Mohammed Z.H. Farooqui,

Patricia Marinello,

Luis A. Díaz

Publication year - 2020

Publication title -

new england journal of medicine

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa2017699

Subject(s) - microsatellite instability , pembrolizumab , colorectal cancer , medicine , cancer , microsatellite , oncology , cancer research , biology , genetics , immunotherapy , allele , gene

Programmed death 1 (PD-1) blockade has clinical benefit in microsatellite-instability-high (MSI-H) or mismatch-repair-deficient (dMMR) tumors after previous therapy. The efficacy of PD-1 blockade as compared with chemotherapy as first-line therapy for MSI-H-dMMR advanced or metastatic colorectal cancer is unknown.

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