Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis | Zendy

Evan S. Dellon | Zendy; Kathryn A. Peterson | Zendy; Joseph A. Murray | Zendy; Gary W. Falk | Zendy; Nirmala Gonsalves | Zendy; Mirna Chehade | Zendy; Robert M. Genta | Zendy; John Leung | Zendy; Paneez Khoury | Zendy; Amy D. Klion | Zendy; Sabine Hazan | Zendy; Michael F. Vaezi | Zendy; Adam C. Bledsoe | Zendy; Sandy Durrani | Zendy; Chao Wang | Zendy; Camilla Shaw | Zendy; Alan T. Chang | Zendy; Bhupinder Singh | Zendy; Amol P. Kamboj | Zendy; Henrik Rasmussen | Zendy; Marc E. Rothenberg | Zendy; Ikuo Hirano | Zendy

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Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis

Author(s) -

Evan S. Dellon,

Kathryn A. Peterson,

Joseph A. Murray,

Gary W. Falk,

Nirmala Gonsalves,

Mirna Chehade,

Robert M. Genta,

John Leung,

Paneez Khoury,

Amy D. Klion,

Sabine Hazan,

Michael F. Vaezi,

Adam C. Bledsoe,

Sandy Durrani,

Chao Wang,

Camilla Shaw,

Alan T. Chang,

Bhupinder Singh,

Amol P. Kamboj,

Henrik Rasmussen,

Marc E. Rothenberg,

Ikuo Hirano

Publication year - 2020

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa2012047

Subject(s) - duodenitis , siglec , gastritis , eosinophilic gastroenteritis , eosinophilic esophagitis , eosinophilic , medicine , antibody , immunology , pathology , gastroenterology , helicobacter pylori , disease

Eosinophilic gastritis and duodenitis are characterized by gastrointestinal mucosal eosinophilia, chronic symptoms, impaired quality of life, and a lack of adequate treatments. Mast-cell activity may contribute to the pathogenesis of the conditions. AK002 (lirentelimab) is an anti-Siglec-8 antibody that depletes eosinophils and inhibits mast cells and that has shown potential in animal models as a treatment for eosinophilic gastritis and duodenitis.

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