Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis | Zendy

Sabrina Pagai | Zendy; Eric A. Macklin | Zendy; Suzanne Hendrix | Zendy; James Berry | Zendy; Michael A. Elliott | Zendy; Samuel Maiser | Zendy; Chafic Karam | Zendy; James B. Caress | Zendy; Margaret Owegi | Zendy; Adam Quick | Zendy; James Wymer | Zendy; Stephen A. Goutman | Zendy; Daragh Heitzman | Zendy; Terry HeimanPatterson | Zendy; Carlayne E. Jackson | Zendy; Colin Quinn | Zendy; Jeffrey D. Rothstein | Zendy; Edward J. Kasarskis | Zendy; Jonathan Katz | Zendy; Liberty Jenkins | Zendy; Shafeeq Ladha | Zendy; Jonathan Mill | Zendy; Stephen N. Scelsa | Zendy; Tuan Vu | Zendy; Christi. Fournier | Zendy; Jonathan D. Glass | Zendy; Kristin Johnson | Zendy; Andrea Swenson | Zendy; Namita Goyal | Zendy; Gary L. Pattee | Zendy; Patricia L. Andres | Zendy; Suma Babu | Zendy; Marianne Chase | Zendy; Derek D’Agostino | Zendy; Samuel P. Dickson | Zendy; Noel Ellison | Zendy; Meghan Hall | Zendy; Kent Hendrix | Zendy; Gale Kittle | Zendy; Michelle McGovern | Zendy; Joseph Ostrow | Zendy; Lindsay Pothier | Zendy; Rebecca Randall | Zendy; Jeremy M. Shefner | Zendy; Alexander Sherman | Zendy; Eric Tustison | Zendy; Prasha Vigneswaran | Zendy; Jason Walker | Zendy; Hong Yu | Zendy; James Chan | Zendy; Janet Wittes | Zendy; Joshua Cohen | Zendy; Justin Klee | Zendy; Kent Leslie | Zendy; Rudolph E. Tanzi | Zendy; Walter Gilbert | Zendy; Patrick Yeramian | Zendy; David Schoenfeld | Zendy; Merit Cudkowicz | Zendy

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Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis

Author(s) -

Sabrina Pagai,

Eric A. Macklin,

Suzanne Hendrix,

James Berry,

Michael A. Elliott,

Samuel Maiser,

Chafic Karam,

James B. Caress,

Margaret Owegi,

Adam Quick,

James Wymer,

Stephen A. Goutman,

Daragh Heitzman,

Terry HeimanPatterson,

Carlayne E. Jackson,

Colin Quinn,

Jeffrey D. Rothstein,

Edward J. Kasarskis,

Jonathan Katz,

Liberty Jenkins,

Shafeeq Ladha,

Jonathan Mill,

Stephen N. Scelsa,

Tuan Vu,

Christi. Fournier,

Jonathan D. Glass,

Kristin Johnson,

Andrea Swenson,

Namita Goyal,

Gary L. Pattee,

Patricia L. Andres,

Suma Babu,

Marianne Chase,

Derek D’Agostino,

Samuel P. Dickson,

Noel Ellison,

Meghan Hall,

Kent Hendrix,

Gale Kittle,

Michelle McGovern,

Joseph Ostrow,

Lindsay Pothier,

Rebecca Randall,

Jeremy M. Shefner,

Alexander Sherman,

Eric Tustison,

Prasha Vigneswaran,

Jason Walker,

Hong Yu,

James Chan,

Janet Wittes,

Joshua Cohen,

Justin Klee,

Kent Leslie,

Rudolph E. Tanzi,

Walter Gilbert,

Patrick Yeramian,

David Schoenfeld,

Merit Cudkowicz

Publication year - 2020

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1916945

Subject(s) - phenylbutyrate , amyotrophic lateral sclerosis , medicine , chemistry , disease

Sodium phenylbutyrate and taurursodiol have been found to reduce neuronal death in experimental models. The efficacy and safety of a combination of the two compounds in persons with amyotrophic lateral sclerosis (ALS) are not known.

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