Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis | Zendy

Bruce C. Trapnell | Zendy; Yoshikazu Inoue | Zendy; Francesco Bonella | Zendy; Cliff Morgan | Zendy; S. Jouneau | Zendy; Elisabeth Bendstrup | Zendy; Ilaria Campo | Zendy; Spyros A. Papiris | Zendy; Etsuro Yamaguchi | Zendy; Erdoğan Çetınkaya | Zendy; M. M. Ilkovich | Zendy; Mordechai R. Kramer | Zendy; Marcel Veltkamp | Zendy; Michael Kreuter | Zendy; Tomohisa Baba | Zendy; Cecilia Ganslandt | Zendy; Inge Tarnow | Zendy; Grant Waterer | Zendy; Taneli Jouhikainen | Zendy

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Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis

Author(s) -

Bruce C. Trapnell,

Yoshikazu Inoue,

Francesco Bonella,

Cliff Morgan,

S. Jouneau,

Elisabeth Bendstrup,

Ilaria Campo,

Spyros A. Papiris,

Etsuro Yamaguchi,

Erdoğan Çetınkaya,

M. M. Ilkovich,

Mordechai R. Kramer,

Marcel Veltkamp,

Michael Kreuter,

Tomohisa Baba,

Cecilia Ganslandt,

Inge Tarnow,

Grant Waterer,

Taneli Jouhikainen

Publication year - 2020

Publication title -

new england journal of medicine

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1913590

Subject(s) - medicine , placebo , inhalation , pulmonary alveolar proteinosis , randomization , anesthesia , clinical endpoint , clinical trial , surgery , lung , pathology , alternative medicine

Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease characterized by progressive surfactant accumulation and hypoxemia. It is caused by disruption of granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling, which pulmonary alveolar macrophages require to clear surfactant. Recently, inhaled GM-CSF was shown to improve the partial pressure of arterial oxygen in patients with aPAP.

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