20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia | Zendy

Ilse K. Luirink | Zendy; Albert Wiegman | Zendy; D. Meeike Kusters | Zendy; Michel H. Hof | Zendy; Jaap W. Groothoff | Zendy; Eric de Groot | Zendy; John J.P. Kastelein | Zendy; Barbara A. Hutten | Zendy

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20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia

Author(s) -

Ilse K. Luirink,

Albert Wiegman,

D. Meeike Kusters,

Michel H. Hof,

Jaap W. Groothoff,

Eric de Groot,

John J.P. Kastelein,

Barbara A. Hutten

Publication year - 2019

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1816454

Subject(s) - medicine , familial hypercholesterolemia , pravastatin , cohort , statin , placebo , cholesterol , incidence (geometry) , intima media thickness , pediatrics , gastroenterology , carotid arteries , pathology , physics , alternative medicine , optics

Familial hypercholesterolemia is characterized by severely elevated low-density lipoprotein (LDL) cholesterol levels and premature cardiovascular disease. The short-term efficacy of statin therapy in children is well established, but longer follow-up studies evaluating changes in the risk of cardiovascular disease are scarce.

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