Bacterial Factors That Predict Relapse after Tuberculosis Therapy | Zendy

Roberto Colangeli | Zendy; Hannah Jedrey | Zendy; Soyeon Kim | Zendy; Roy Connell | Zendy; Shuyi Ma | Zendy; Uma Deepthi Chippada Venkata | Zendy; Soumitesh Chakravorty | Zendy; Aditi Gupta | Zendy; Erin Sizemore | Zendy; Lois Diem | Zendy; David R. Sherman | Zendy; Alphonse Okwera | Zendy; Reynaldo Dietze | Zendy; W. Henry Boom | Zendy; John L. Johnson | Zendy; William R. Mac Kenzie | Zendy; David Alland | Zendy

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Bacterial Factors That Predict Relapse after Tuberculosis Therapy

Author(s) -

Roberto Colangeli,

Hannah Jedrey,

Soyeon Kim,

Roy Connell,

Shuyi Ma,

Uma Deepthi Chippada Venkata,

Soumitesh Chakravorty,

Aditi Gupta,

Erin Sizemore,

Lois Diem,

David R. Sherman,

Alphonse Okwera,

Reynaldo Dietze,

W. Henry Boom,

John L. Johnson,

William R. Mac Kenzie,

David Alland

Publication year - 2018

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1715849

Subject(s) - tuberculosis , medicine , intensive care medicine , pathology

Approximately 5% of patients with drug-susceptible tuberculosis have a relapse after 6 months of first-line therapy, as do approximately 20% of patients after 4 months of short-course therapy. We postulated that by analyzing pretreatment isolates of Mycobacterium tuberculosis obtained from patients who subsequently had a relapse or were cured, we could determine any correlations between the minimum inhibitory concentration (MIC) of a drug below the standard resistance breakpoint and the relapse risk after treatment.

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