Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination | Zendy

Elisa Nemes | Zendy; Hennie Geldenhuys | Zendy; Virginie Rozot | Zendy; Kathryn Rutkowski | Zendy; Frances Ratangee | Zendy; Nicole Bilek | Zendy; Simbarashe Mabwe | Zendy; Lebohang Makhethe | Zendy; Mzwandile Erasmus | Zendy; Asma Toefy | Zendy; Humphrey Mulenga | Zendy; Willem A. Hanekom | Zendy; Steven G. Self | Zendy; LindaGail Bekker | Zendy; Robert Ryall | Zendy; Sanjay Gurunathan | Zendy; Carlos A. DiazGranados | Zendy; Peter Andersen | Zendy; Ingrid Kromann | Zendy; Thomas G. Evans | Zendy; Ruth D. Ellis | Zendy; Bernard Landry | Zendy; David A. Hokey | Zendy; Robert Hopkins | Zendy; Ann M. Ginsberg | Zendy; Thomas J. Scriba | Zendy; Mark Hatherill | Zendy

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Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

Author(s) -

Elisa Nemes,

Hennie Geldenhuys,

Virginie Rozot,

Kathryn Rutkowski,

Frances Ratangee,

Nicole Bilek,

Simbarashe Mabwe,

Lebohang Makhethe,

Mzwandile Erasmus,

Asma Toefy,

Humphrey Mulenga,

Willem A. Hanekom,

Steven G. Self,

LindaGail Bekker,

Robert Ryall,

Sanjay Gurunathan,

Carlos A. DiazGranados,

Peter Andersen,

Ingrid Kromann,

Thomas G. Evans,

Ruth D. Ellis,

Bernard Landry,

David A. Hokey,

Robert Hopkins,

Ann M. Ginsberg,

Thomas J. Scriba,

Mark Hatherill

Publication year - 2018

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1714021

Subject(s) - medicine , virology , tuberculosis , bcg vaccine , vaccination , immunology , tuberculosis vaccines , mycobacterium tuberculosis , pathology

Recent Mycobacterium tuberculosis infection confers a predisposition to the development of tuberculosis disease, the leading killer among global infectious diseases. H4:IC31, a candidate subunit vaccine, has shown protection against tuberculosis disease in preclinical models, and observational studies have indicated that primary bacille Calmette-Guérin (BCG) vaccination may offer partial protection against infection.

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