Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy | Zendy

Shigeru Kinoshita | Zendy; Noriko Koizumi | Zendy; Morio Ueno | Zendy; Naoki Okumura | Zendy; Kojiro Imai | Zendy; Hiroshi Tanaka | Zendy; Yuji Yamamoto | Zendy; Takahiro Nakamura | Zendy; Tsutomu Inatomi | Zendy; John Bush | Zendy; Munetoyo Toda | Zendy; Michio Hagiya | Zendy; Isao Yokota | Zendy; Satoshi Teramukai | Zendy; Chie Sotozono | Zendy; Junji Hamuro | Zendy

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Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy

Author(s) -

Shigeru Kinoshita,

Noriko Koizumi,

Morio Ueno,

Naoki Okumura,

Kojiro Imai,

Hiroshi Tanaka,

Yuji Yamamoto,

Takahiro Nakamura,

Tsutomu Inatomi,

John Bush,

Munetoyo Toda,

Michio Hagiya,

Isao Yokota,

Satoshi Teramukai,

Chie Sotozono,

Junji Hamuro

Publication year - 2018

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1712770

Subject(s) - cornea , medicine , bullous keratopathy , ophthalmology , visual acuity , corneal diseases , corneal collagen cross linking , keratoconus

Corneal endothelial cell (CEC) disorders, such as Fuchs's endothelial corneal dystrophy, induce abnormal corneal hydration and result in corneal haziness and vision loss known as bullous keratopathy. We investigated whether injection of cultured human CECs supplemented with a rho-associated protein kinase (ROCK) inhibitor into the anterior chamber could increase CEC density.

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