Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides | Zendy

Mark J. Graham | Zendy; Richard Lee | Zendy; Teresa Brandt | Zendy; Bruce L. Tai | Zendy; Wuxia Fu | Zendy; Raechel Peralta | Zendy; Rosie Z. Yu | Zendy; Eunju Hurh | Zendy; Erika Paz | Zendy; Bradley McEvoy | Zendy; Brenda F. Baker | Zendy; Nguyen C. Pham | Zendy; Andrés Digenio | Zendy; Steven G. Hughes | Zendy; Richard S. Geary | Zendy; Joseph L. Witztum | Zendy; Rosanne M. Crooke | Zendy; Sotirios Tsimikas | Zendy

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Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

Author(s) -

Mark J. Graham,

Richard Lee,

Teresa Brandt,

Bruce L. Tai,

Wuxia Fu,

Raechel Peralta,

Rosie Z. Yu,

Eunju Hurh,

Erika Paz,

Bradley McEvoy,

Brenda F. Baker,

Nguyen C. Pham,

Andrés Digenio,

Steven G. Hughes,

Richard S. Geary,

Joseph L. Witztum,

Rosanne M. Crooke,

Sotirios Tsimikas

Publication year - 2017

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1701329

Subject(s) - medicine , triglyceride , endocrinology , apolipoprotein b , lipoprotein , cholesterol , pcsk9 , pharmacodynamics , pharmacokinetics , ldl receptor

Epidemiologic and genomewide association studies have linked loss-of-function variants in ANGPTL3, encoding angiopoietin-like 3, with low levels of plasma lipoproteins.

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